Blumberg B S, Gerstley B J S, Hungerford D A, London W T & Sutnick A I. A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis. Ann. Intern. Med. 66:924-31, 1967
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چکیده
This is the first paper in which it was stated that Australia antigen (Au) was the hepatitis virus. This subsequently led to the identification of the hepatitis B virus (HBV), the development of methods for the diagnosis of hepatitis B, the prevention of post-transfusion hepatitis, the control of hepatitis in high risk environments, a vaccine against hepatitis B, and the recognition of the role of HBV in the causation of primary hepatocellular carcinoma (PHC). [The SCI indicates that this paper has been cited in over 480 publications since 1967.]
منابع مشابه
A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis.
WE H A V E P R E V I O U S L Y R E P O R T E D T H E P R C S ence of an Lsoanugen of human sera, rare o r absent in normal U, S. and northern European populations bui relatively com mon in patients with leukemia (I, 2). T h e "new" isoantigen has been tailed '"Aus t r a l i a a n t i g e n " because i t was first found in the serum of an Australian aborigine. I t a p p e a r s t o b e d i f f...
متن کاملThe Localization of Australia Antigen by Immunofluorescence
We have studied the localization of Australia antigen, a particulate substance associated with hepatitis, by means of the fluorescent antibody technique. Preparations were made from 61 liver biopsy specimens taken from patients with infectious hepatitis, serum hepatitis, and a variety of other diseases. When tested with fluorescein-conjugated rabbit anti-Au(1) antisera all 26 patients who had A...
متن کاملAustralia antigen and antibody in transfused children with thalassaemia.
Vierucci, A., London, W. T., Blumberg, B. S., Sutnick, A. I., and Ragazzini (1972). Archives of Disease in Childhood, 47, 760. Australia antigen and antibody in transfused children with thalassaemia. As a consequence of frequent transfusions, 10% of 169 Italian patients with thalassaemia developed Au(1) and 20% anti-Au(I). Au(l) persisted in the children in whom it was detected for the duration...
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Ackerman, N. B., Shahon, D. B., McFee, A. S., and Wangensteen, 0. H. (1960). Ann. Surg., 152, 602. Ashizawa, S. (1966). Personal communication. Blendis, L. M., Cameron, A. J., and Hadley, G. D. (1967). Gut. To be published. Burnett, W., MacFarlane, P. S., Park, S. D. S., and Kay, A. W. (1960). Brit. med. 7., 1, 753. Chrysospathis, P. (1963). Surgery, 54, 292. Cummins, A. I., Gompertz, M. L., an...
متن کاملAustralia antigen and heaptitis: a review.
The description of Australia antigen by Blumberg, Alter, and Visnich in 1965, and the subsequent discovery of its association with hepatitis (Blumberg, Sutnick, and London, 1968) have stimulated renewed interest in the disease. The antigen occurs in the serum during the acute phase of illness and seems to be closely associated with infectivity. In this review our knowledge of its properties wil...
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